Interactive Non-monotonicity Explorer
The figure below can be used to explore how changing the wild type values of Ka and/or Ki by different factors (θ or θ1/θ2), keeping all other parameters between the mutant and wild-type the same, can result in non-monotonic behavior of ∆F. See the supplement for a more detailed definition of the non-monotonic dependence. This figure was generated using the Bokeh interactive plotting framework and the code used to generate it can be accessed via the code page of this website.